The role of long noncoding RNA in lipid, cholesterol, and glucose metabolism and treatment of obesity syndrome
Autor: | Aimei Liu, Arturo Anadón, Irma Ares, María-Aránzazu Martínez, Xu Wang, Pu Guo, Qirong Lu, María-Rosa Martínez-Larrañaga |
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Rok vydání: | 2020 |
Předmět: |
Carbohydrate metabolism
Biology Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine Humans Obesity Epigenetics Gene 030304 developmental biology Pharmacology 0303 health sciences Cholesterol Metabolism Lipid Metabolism medicine.disease Long non-coding RNA Glucose chemistry 030220 oncology & carcinogenesis Molecular Medicine RNA Long Noncoding Signal transduction |
Zdroj: | Medicinal Research Reviews. 41:1751-1774 |
ISSN: | 1098-1128 0198-6325 |
Popis: | Obesity syndromes, characterized by abnormal lipid, cholesterol, and glucose metabolism, are detrimental to human health and cause many diseases, including obesity and type II diabetes. Increasing evidence has shown that long noncoding RNA (lncRNA), transcripts longer than 200 nucleotides that are not translated into proteins, play an important role in regulating abnormal metabolism in obesity syndromes. For the first time, we systematically summarize how lncRNA is involved in complex obesity metabolic syndromes, including the regulation of lipid, cholesterol, and glucose metabolism. Moreover, we discuss lncRNA involvement in food intake that mediates obesity syndromes. Furthermore, this review might shed new light on a lncRNA-based strategy for the prevention and treatment of obesity syndromes. Recent investigations support that lncRNA is a novel molecular target of obesity syndromes and should be emphasized. Namely, lncRNA plays a crucial role in the development of obesity syndrome process. Various lncRNAs are involved in the process of lipid, cholesterol, and glucose metabolism by regulating gene transcription, signaling pathway, and epigenetic modification of metabolism-related genes, proteins, and enzymes. Food intake could also induce abnormal expression of lncRNA associated with obesity syndrome, especially high-fat diet. Notably, some nanomolecules and natural extracts may target lncRNAs, associated with obesity syndrome, as a potential treatment for obesity syndromes. |
Databáze: | OpenAIRE |
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