Building up DNA, bit by bit: a simple description of chain assembly
| Autor: | José Maria Tavares, Francesco Sciortino, Paulo Ivo Cortez Teixeira, Riccardo Foffi |
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| Rok vydání: | 2021 |
| Předmět: |
Physics
Quantitative Biology::Biomolecules Polymers Assembly FOS: Physical sciences DNA General Chemistry Condensed Matter - Soft Condensed Matter Condensed Matter Physics Chemical reaction Polymerization Bit (horse) chemistry.chemical_compound Chain (algebraic topology) chemistry Simple (abstract algebra) Soft Condensed Matter (cond-mat.soft) Thermodynamics Ideal (order theory) Statistical physics Perturbation theory Patchy particles |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1744-6848 1744-683X |
| DOI: | 10.1039/d1sm01130h |
| Popis: | We simulate the assembly of DNA copolymers from two types of short duplexes (short double strands with a single-stranded overhang at each end), as described by the oxDNA model. We find that the statistics of chain lengths can be well reproduced by a simple theory that treats the association of particles into ideal (i.e., non-interacting) clusters as a reversible chemical reaction. The reaction constants can be predicted either from Santalucia's theory or from Wertheim's thermodynamic perturbation theory of association for spherical patchy particles. Our results suggest that theories incorporating very limited molecular detail may be useful for predicting the broad equilibrium features of copolymerisation. 22 pages, 5 figures. To be published in Soft Matter |
| Databáze: | OpenAIRE |
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