The involvement of TRPV1 in emesis and anti-emesis
| Autor: | Eugene Nalivaiko, Christina Wan, Paul L.R. Andrews, John A. Rudd, Norio Matsuki |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
vomiting
12-HPETE 12-hydroperoxy-eicosatetraenoic acid Physiology Substance P Review CP 99 994 capsaicin CGRP calcitonin gene-related peptide CINV chemotherapy-induced nausea and vomiting chemistry.chemical_compound NK1 neurokinin1 anti-emetic Endorphins ferret FAAH fatty acid amide hydrolase thermoregulation 5-HT 5-hydroxytryptamine Area postrema NADA N-arachidonoyl-dopamine nausea BBB blood brain barrier AP area postrema D2 dopamine2 H1 histamine1 medicine.drug medicine.medical_specialty LTB4 leukotriene B4 AM404 Resiniferatoxin TRPV1 RTX Dopamine i.v. intravenous Physiology (medical) Internal medicine 5-HT3 5-hdroxytryptamine3 medicine AMT anandamide membrane transporter CVO's circumventricular organs AM404 N-arachidonoylaminophenol 8-OH-DPAT (±)-8-Hydroxy-2-dipropylaminotetralin CTA conditioned taste aversion DRG dorsal root ganglia Endocrinology chemistry vanilloid Capsaicin Suncus murinus Reflex POAH preoptic anterior hypothalamus CB1 cannabinoid1 TRPV1 transient receptor potential vanilloid receptor1 olvanil |
| Zdroj: | Temperature: Multidisciplinary Biomedical Journal |
| ISSN: | 2332-8959 2332-8940 |
| DOI: | 10.1080/23328940.2015.1043042 |
| Popis: | Diverse transmitter systems (e.g. acetylcholine, dopamine, endocannabinoids, endorphins, glutamate, histamine, 5-hydroxytryptamine, substance P) have been implicated in the pathways by which nausea and vomiting are induced and are targets for anti-emetic drugs (e.g. 5-hydroxytryptamine3 and tachykinin NK1 antagonists). The involvement of TRPV1 in emesis was discovered in the early 1990s and may have been overlooked previously as TRPV1 pharmacology was studied in rodents (mice, rats) lacking an emetic reflex. Acute subcutaneous administration of resiniferatoxin in the ferret, dog and Suncus murinus revealed that it had “broad–spectrum” anti-emetic effects against stimuli acting via both central (vestibular system, area postrema) and peripheral (abdominal vagal afferents) inputs. One of several hypotheses discussed here is that the anti-emetic effect is due to acute depletion of substance P (or another peptide) at a critical site (e.g. nucleus tractus solitarius) in the central emetic pathway. Studies in Suncus murinus revealed a potential for a long lasting (one month) effect against the chemotherapeutic agent cisplatin. Subsequent studies using telemetry in the conscious ferret compared the anti-emetic, hypothermic and hypertensive effects of resiniferatoxin (pungent) and olvanil (non-pungent) and showed that the anti-emetic effect was present (but reduced) with olvanil which although inducing hypothermia it did not have the marked hypertensive effects of resiniferatoxin. The review concludes by discussing general insights into emetic pathways and their pharmacology revealed by these relatively overlooked studies with TRPV1 activators (pungent an non-pungent; high and low lipophilicity) and antagonists and the potential clinical utility of agents targeted at the TRPV1 system. |
| Databáze: | OpenAIRE |
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