An atypical cutaneous presentation of vasculitis with features of ChurgâStrauss syndrome, associated with anti-neutrophil cytoplasmic antibodies and anti-glomerular basement membrane antibodies
| Autor: | Alistair Robson, H. T. Cook, C. M. Gleeson, Nicholas Francis, F. M. Pope, J. B. Levy |
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| Rok vydání: | 2009 |
| Předmět: |
Vasculitis
Pathology medicine.medical_specialty Dermatology Churg-Strauss Syndrome Antibodies Antineutrophil Cytoplasmic Eosinophilia Humans Medicine Fibrinoid necrosis Autoantibodies Anti-neutrophil cytoplasmic antibody medicine.diagnostic_test business.industry Glomerular basement membrane Overlap syndrome Middle Aged medicine.disease Treatment Outcome medicine.anatomical_structure Skin biopsy Female Renal biopsy medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Clinical and Experimental Dermatology. 34:e577-e580 |
| ISSN: | 1365-2230 0307-6938 |
| Popis: | We report the case of a 59-year-old woman who presented with a persistent papular and nodular cutaneous eruption and new-onset asthma, with normal renal function but persistent haematuria and proteinuria. Investigations revealed eosinophilia, both antineutrophil cytoplasmic antibodies and antiglomerular basement membrane antibodies on serological testing (double-positive vasculitis), and a focal necrotizing glomerulonephritis on renal biopsy. Histological examination of a skin biopsy showed a dense neutrophilic infiltrate with focal fibrinoid necrosis and few eosinophils. The clinical and pathological features suggested a double-positive vasculitis/Churg-Strauss overlap syndrome presenting with a predominantly neutrophilic dermatosis. Specific cutaneous features in patients with double-positive vasculitis have not been documented previously. The patient has responded extremely well to immunosuppressive treatment and her disease is currently in remission. |
| Databáze: | OpenAIRE |
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