In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori
| Autor: | Beata Wielgus-Kutrowska, Igor Stuparević, Marta Łyczek, Agnieszka Bzowska, Marija Luić, Natalia Mrnjavac, Ante Bubić, Ivana Leščić Ašler |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Glycine Context (language use) Human pathogen adenylosuccinate synthetase Microbiology Adenylosuccinate Synthase Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Antibiotic resistance enzyme kinetics Drug Discovery Enzyme Inhibitors Purine metabolism Pathogen enzyme inhibition Pharmacology Dose-Response Relationship Drug Molecular Structure 030102 biochemistry & molecular biology biology Helicobacter pylori oligomeric state analytical ultracentrifugation lcsh:RM1-950 Adenylosuccinate synthase General Medicine biology.organism_classification Adenosine Monophosphate Chemistry 030104 developmental biology lcsh:Therapeutics. Pharmacology chemistry Adenylosuccinate biology.protein Research Paper |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1405-1414 (2018) Journal of Enzyme Inhibition and Medicinal Chemistry |
| ISSN: | 1475-6374 1475-6366 |
| Popis: | Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter pylori, a wide-spread human pathogen involved in the development of many diseases. The rate of H. pylori antibiotic resistance is on the increase, making the quest for new drugs against this pathogen more important than ever. In this context, we describe here the properties of H. pylori AdSS. This enzyme exists in a dimeric active form independently of the presence of its ligands. Its narrow stability range and pH-neutral optimal working conditions reflect the bacterium’s high level of adaptation to its living environment. Efficient inhibition of H. pylori AdSS with hadacidin and adenylosuccinate gives hope of finding novel drugs that aim at eradicating this dangerous pathogen. |
| Databáze: | OpenAIRE |
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