Novel and emerging devices and operations in the treatment of obesity in children and adolescents
| Autor: | Hae Sung Kang, David Lanning, Jonathan H. DeAntonio, Allen Browne, Claudio Oiticica |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Pediatric Obesity medicine.medical_specialty Adolescent Energy (esotericism) Bariatric Surgery Public policy Affect (psychology) Endoscopy Gastrointestinal Energy homeostasis 03 medical and health sciences 0302 clinical medicine Weight loss 030225 pediatrics Epidemiology medicine Humans Child business.industry Public health medicine.disease Obesity 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Laparoscopy Surgery medicine.symptom business |
| Zdroj: | Seminars in Pediatric Surgery. 29:150881 |
| ISSN: | 1055-8586 |
| DOI: | 10.1016/j.sempedsurg.2020.150881 |
| Popis: | Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income groups, and increasingly affects children as well as adults. A lack of effective options for long-term weight reduction magnifies the enormity of this problem; individuals who successfully complete behavioral and dietary weight-loss programs eventually regain most of the lost weight. We included evidence from basic science, clinical, and epidemiological literature to assess current knowledge regarding mechanisms underlying excess body-fat accumulation, the biological defense of excess fat mass, and the tendency for lost weight to be regained. A major area of emphasis is the science of energy homeostasis, the biological process that maintains weight stability by actively matching energy intake to energy expenditure over time. Growing evidence suggests that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight. We need to elucidate the mechanisms underlying this "upward setting" or "resetting" of the defended level of body-fat mass, whether inherited or acquired. The ongoing study of how genetic, developmental, and environmental forces affect the energy homeostasis system will help us better understand these mechanisms and are therefore a major focus of this statement. The scientific goal is to elucidate obesity pathogenesis so as to better inform treatment, public policy, advocacy, and awareness of obesity in ways that ultimately diminish its public health and economic consequences. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect