Effect of Y-516 on the hyperactivity induced by dopamine injected bilaterally into the nucleus accumbens
| Autor: | Michihide Setoguchi, Takemi Fukuda, Toshihiko Morimoto, Yasuto Morimoto |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pharmacology Nialamide Dose-Response Relationship Drug Chemistry Dopamine Dopaminergic Rats Inbred Strains Benzazepines Hyperkinesis Nucleus accumbens Clocapramine Nucleus Accumbens Rats Tranquilizing Agents Dopamine receptor D1 medicine Haloperidol Animals Dopamine Antagonists Chlorpromazine Injections Intraventricular medicine.drug |
| Zdroj: | Folia Pharmacologica Japonica. 96:65-71 |
| ISSN: | 1347-8397 0015-5691 |
| Popis: | The effect of Y-516 on the hyperactivity induced by dopamine injected bilaterally into the nucleus accumbens was compared with those of clocapramine (CCP), haloperidol (HPD) and chlorpromazine (CPZ). Dopamine (5-50 micrograms) injected into the nucleus accumbens induced a dose-dependent hyperactivity following pretreatment with nialamide (100 mg/kg, i.p., 2 hr). The hyperactivity induced by 10 micrograms of dopamine was antagonized by the i.p. administration of Y-516 (0.5-1.0 mg/kg), CCP (5-25 mg/kg), HPD (0.05-0.5 mg/kg) and CPZ (1-5 mg/kg) in a dose-dependent manner. The ED50 values of Y-516, CCP, HPD and CPZ were 0.85, 16.5, 0.098 and 2.53 mg/kg, respectively. These results suggest that Y-516 has a potential inhibitory effect on the mesolimbic dopaminergic system and may be a beneficial neuroleptic drugs. |
| Databáze: | OpenAIRE |
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