Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling
Autor: | Jin Kyung Kim, Eun-Kyeong Jo, Hyun-Woo Suh, Hyo Sun Jin |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Inflammasomes Immunology Models Biological Pyrin domain 03 medical and health sciences AIM2 NLR Family Pyrin Domain-Containing 3 Protein medicine Animals Humans Immunology and Allergy Caspase integumentary system biology Effector Signal transducing adaptor protein Inflammasome Cell Biology Cell biology 030104 developmental biology biology.protein Signal transduction NLRP3 inflammasome complex Signal Transduction medicine.drug |
Zdroj: | Immunology & Cell Biology. 95:584-592 |
ISSN: | 1440-1711 0818-9641 |
Popis: | Inflammasomes are cytosolic multiprotein complexes that cause the release of biologically active interleukin-1β. The best-characterized inflammasome is the NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 or Nod-like receptor protein 3) inflammasome. The NLRP3 inflammasome forms an assembly consisting of the ASC (apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain) adaptor protein and the effector, caspase-1 (cysteine-dependent aspartate-directed protease-1). Numerous agents and ligands derived from pathogens, modified self-cells and the environment induce NLRP3 inflammasome complex formation. NLRP3 inflammasome activation is tightly controlled at the transcriptional and post-translational levels to prevent unwanted excessive inflammation. Recent studies have highlighted the roles and mechanisms of several negative regulators that inhibit the assembly of NLRP3 inflammasome complexes and suppress inflammatory responses. The identification and characterization of new players in the regulation of NLRP3 inflammasome may lead to the development of inflammasome-targeting therapeutics against various inflammatory diseases related to NLRP3 inflammasome-associated pathogenesis. |
Databáze: | OpenAIRE |
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