Erythrocyte Deformability in Children With Autism Spectrum Disorder: Correlation With Clinical Features
| Autor: | Daniela Ostatníková, Hana Celušáková, Dominika Radosinska, Tomas Jasenovec, Katarina Babinska, Jana Radosinska, D. Filcikova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Autism Spectrum Disorder Physiology Disease Clinical manifestation Bioinformatics Correlation Pathogenesis 03 medical and health sciences 0302 clinical medicine Erythrocyte Deformability mental disorders medicine Humans Erythrocyte deformability Child Psychological Tests business.industry General Medicine medicine.disease 030104 developmental biology Autism spectrum disorder Child Preschool Etiology Autism Female business 030217 neurology & neurosurgery |
| Zdroj: | Physiological Research. :S307-S313 |
| ISSN: | 1802-9973 0862-8408 |
| Popis: | Biomechanical properties of erythrocytes play an important role in health and disease. Deformability represents intrinsic property of erythrocytes to undergo deformation that is crucial for their passage through the narrow capillaries. The erythrocyte damage can lead to compromised tissue perfusion and consequently play a role in the pathogenesis of various diseases including neurological ones. Data available in databases indicate that erythrocytes in autism spectrum disorder (ASD) are altered. This may affect the clinical symptoms of ASD. The aim of our study was to determine erythrocyte deformability in 54 children with ASD and correlate it with clinical symptoms. We found significant negative correlation between erythrocyte deformability and score in C domain of the Autism Diagnostic Interview-Revised (ADI-R) diagnostic tool describing the measure of restrictive, repetitive, and stereotyped behaviors and interests, mainly observable in C1 and C2, but not in C3 and C4 subdomains. This supports the findings of other authors and suggest that behavioral domain C comprises of more subcategories with different underlying etiology. Our results also indicate that abnormalities in erythrocyte deformability may be involved in ASD pathomecha-nisms and contribute to its clinical manifestation. Further research is necessary to bring more data and identify erythrocyte deformability as prognostic biomarker in ASD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|