Plasma homovanillic acid and tardive dyskinesia during neuroleptic maintenance and withdrawal
| Autor: | Susan Hattox, Darrell Kirch, Robert Freedman, Jon Bell, Robert P. Murphy |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced Metabolite Tardive dyskinesia chemistry.chemical_compound Dopamine medicine Humans Biological Psychiatry Phenylacetates Mental Disorders Dopaminergic Homovanillic acid Homovanillic Acid Plasma levels Middle Aged medicine.disease Psychiatry and Mental health chemistry Anesthesia Significant positive correlation Female Abnormal Involuntary Movement Scale Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Psychiatry Research. 9:217-223 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(83)90046-x |
| Popis: | Plasma levels of homovanillic acid (HVA), a dopamine metabolite, were examined in 19 psychiatric inpatients during maintenance treatment on neuroleptic medications. A significant positive correlation was found between the level of HVA and the severity of tardive dyskinesia (TD) in these patients. Seven patients had their medication discontinued for 12 days. In spite of a fall in neuroleptic levels to negligible values, plasma HVA levels remained essentially stable while scores on the Abnormal Involuntary Movement Scale (AIMS) fell only slightly. The data support the hypothesis that some forms of TD may involve a persistent increase in presynaptic dopaminergic activity. |
| Databáze: | OpenAIRE |
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