Circadian Variations of Luteinizing Hormone Can Have Two Different Profiles in Adolescent Anovulation
| Autor: | Carlo Flamigni, Raffaella Fabbri, Eleonora Porcu, O. Magrini, Daniela Gabbi, Roberto Paradisi, Roberto Bolzani, Stefano Venturoli |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Biology Biochemistry Lh pulse Anovulation Endocrinology Internal medicine medicine Humans Circadian rhythm Androstenedione Testosterone Pulse (signal processing) Puberty Biochemistry (medical) Luteinizing Hormone medicine.disease Circadian Rhythm Plasma LH level Follicular Phase Female Follicle Stimulating Hormone Luteinizing hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 65:488-493 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-65-3-488 |
| Popis: | The circadian profile of plasma LH concentrations was investigated in 12 healthy anovulatory adolescent women by drawing blood samples every 20 min for 24 h during the early follicular phase. Plasma 17 beta-estradiol, testosterone, and androstenedione levels were measured in the first sample. Ovarian size was measured by ultrasound. According to their mean plasma LH levels, the adolescents were divided into two groups, those with a high plasma LH level (2 Sd or greater than the mean adult value) and those with a normal plasma LH level. The mean plasma estradiol (P less than 0.001) and testosterone (P less than 0.05) levels were higher in the women with high plasma LH levels compared to those in women with normal plasma LH levels. The LH pulse amplitude was greater (P less than 0.05) and the interpulse interval shorter (P less than 0.025) in the high LH group compared to those in the normal LH group. A 24-h periodicity with the highest plasma LH levels and the greatest pulse amplitude in the afternoon was found in high LH group. In the normal LH group, the highest plasma LH levels and greatest pulse amplitude occurred in the first hours of the morning. An accentuated 24-h LH periodicity is typical of puberty, but disappears in adulthood. We have recorded the persistence of pronounced LH circadian changes in anovulatory adolescent women which might be a marker of a continuing maturational process. Furthermore, LH circadian changes have opposing profiles according to the mean LH values, suggesting the presence of different central nervous system pubertal programs. |
| Databáze: | OpenAIRE |
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