Coupled potassium channels induced by arachidonic acid in cultured neurons
| Autor: | L. S. Premkumar, Shin-Ho Chung, Peter W. Gage |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Potassium Channels Potassium chemistry.chemical_element Arachidonic Acids Hippocampal formation Hippocampus General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Electrochemistry Animals Cells Cultured General Environmental Science Neurons Arachidonic Acid General Immunology and Microbiology Chemistry General Medicine Potassium channel Electrophysiology Membrane Baclofen Endocrinology medicine.anatomical_structure Biophysics Arachidonic acid Neuron General Agricultural and Biological Sciences |
| Zdroj: | Proceedings. Biological sciences. 242(1303) |
| ISSN: | 0962-8452 |
| Popis: | Exposure of the inside surface of patches of membrane excised from cultured rat hippocampal neurons to arachidonic acid (10-100 $\mu $M) caused the appearance of potassium currents of variable amplitude similar to those activated by GABA or baclofen in cell-attached patches. The amplitude of single-channel currents increased with time after exposure to 20 or 50 $\mu $M arachidonic acid and also increased when arachidonic acid concentration was increased from 20 to 50 or 100 $\mu $M. Current-amplitude probability histograms had peaks at integral multiples of an `elementary' current. It is proposed that arachidonic acid or its metabolites cause synchronous opening and closing of coupled conducting units (co-channels) in cell membranes. |
| Databáze: | OpenAIRE |
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