Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite
| Autor: | Domingos Hiroshi Tsuji, Rodrigo Augusto de Souza Leão, Sidcley Bernardino-Araújo, Silvio José de Vasconcelos, Mariana Montenegro de Melo Lira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Time Factors RD1-811 chemistry.chemical_element Biocompatible Materials Vocal Cords engineering.material Calcium Giant Cells Severity of Illness Index Injections Neovascularization Random Allocation Laryngoplasty Laryngitis Biopolymers Fibrosis Internal medicine medicine Animals Random allocation Neovascularization Pathologic Chemistry Anatomy medicine.disease Dysphonia Saccharum Endocrinology Durapatite Polymorphonuclear cells Giant cell engineering Surgery Biopolymer Hydroxyapatites Rabbits medicine.symptom |
| Zdroj: | Acta Cirurgica Brasileira, Vol 30, Iss 3, Pp 186-193 (2015) Acta Cirúrgica Brasileira v.30 n.3 2015 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 30, Issue: 3, Pages: 186-193, Published: MAR 2015 |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE:To compare the inflammatory reaction caused by the injection of a sugarcane biopolymer (SCB) into the vocal fold of rabbits with that caused by calcium hydroxyapatite (CaH).METHODS: CaH (Radiesse(r)) and SCB gel were injected respectively into the right and left vocal cords of thirty rabbits. The rabbits were distributed into two equal groups and sacrificed at three and twelve weeks after injection. We then evaluated the intensity of the inflammatory reaction, plus levels of neovascularization, fibrogenesis and inflammatory changes in the vocal mucosa.RESULTS:The vocal cords injected with CaH had a stronger inflammatory reaction by giant cells in both study periods. The SCB group had a more intense inflammatory involvement of polymorphonuclear cells three weeks after injection. SCB caused a higher level of neovascularization compared with CaH three weeks after the procedure.CONCLUSION:Whereas calcium hydroxyapatite triggers a more intense and lasting inflammatory reaction mediated by giant cells, sugarcane biopolymer causes a greater response from polymorphonuclear leukocytes, as well as higher levels of vneoascularization three weeks after injection. |
| Databáze: | OpenAIRE |
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