MPO Activity and Generation of Active O2 Species in Leukocytes From Poorly Controlled Diabetic Patients
| Autor: | Isao Kobayashi, Masatomo Mori, Noriyuki Sato, Hiroyuki Shimizu, Yohnosuke Shimomura, Kunihiko Suwa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Slope gradient chemistry.chemical_compound Reference Values Superoxides Diabetes mellitus Internal medicine Leukocytes Internal Medicine medicine Humans Peroxidase Glycated Hemoglobin Advanced and Specialized Nursing Superoxide business.industry Zymosan Non insulin dependent diabetes mellitus medicine.disease Endocrinology Diabetes Mellitus Type 2 chemistry Female Peak value business Biomarkers |
| Zdroj: | Diabetes Care. 15:1050-1052 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.15.8.1050 |
| Popis: | OBJECTIVE This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM. RESEARCH DESIGN AND METHODS Superoxide anion (O2−) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDM patients (FBG >8.89 mM, HbA1 >10%). RESULTS In diabetic subjects, both O2− production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects. CONCLUSIONS This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabetic patients. |
| Databáze: | OpenAIRE |
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