Antibody-Mediated Elimination of the Obligate Intracellular Bacterial PathogenEhrlichia chaffeensisduring Active Infection
| Autor: | Andrew A. Reilly, Frederick K. Chu, Gary M. Winslow, Konstantin Shilo, Eric J. Yager, Erin L Volk |
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| Rok vydání: | 2000 |
| Předmět: |
Cellular immunity
Time Factors Ehrlichiosis T-Lymphocytes Blotting Western Immunology Receptors Antigen T-Cell Fluorescent Antibody Technique Mice SCID Biology Microbiology Cell Line Mice Dogs Immune system Immunity medicine Animals Ehrlichia chaffeensis Host Response and Inflammation Antigens Bacterial B-Lymphocytes Errata Intracellular parasite Immunization Passive medicine.disease biology.organism_classification Antibodies Bacterial Virology Mice Inbred C57BL Blood Infectious Diseases Liver Humoral immunity biology.protein Parasitology Antibody Spleen |
| Zdroj: | Infection and Immunity. 68:2187-2195 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.68.4.2187-2195.2000 |
| Popis: | It is generally accepted that cellular, but not humoral immunity, plays an important role in host defense against intracellular bacteria. However, studies of some of these pathogens have provided evidence that antibodies can provide immunity if present during the initiation of infection. Here, we examined immunity against infection byEhrlichia chaffeensis, an obligate intracellular bacterium that causes human monocytic ehrlichiosis. Studies with mice have demonstrated that immunocompetent strains are resistant to persistent infection but that SCID mice become persistently and fatally infected. Transfer of immune serum or antibodies obtained from immunocompetent C57BL/6 mice to C57BL/6scidmice provided significant although transient protection from infection. Bacterial clearance was observed when administration occurred at the time of inoculation or well after infection was established. The effect was dose dependent, occurred within 2 days, and persisted for as long as 2 weeks. Weekly serum administration prolonged the survival of susceptible mice. Although cellular immunity is required for complete bacterial clearance, the data show that antibodies can play a significant role in the elimination of this obligate intracellular bacterium during active infection and thus challenge the paradigm that humoral responses are unimportant for immunity to such organisms. |
| Databáze: | OpenAIRE |
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