An overview on dietary polyphenols and their biopharmaceutical classification system (Bcs)
Autor: | Camilla Tibaldi, Francesca Truzzi, Eros D′Amen, Giovanni Dinelli, Yanxin Zhang |
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Přispěvatelé: | Truzzi F., Tibaldi C., Zhang Y., Dinelli G., D'Amen E. |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Flavonols
Bioavailability LogP Review Coumaric Acid 030226 pharmacology & pharmacy Ferulic acid chemistry.chemical_compound 0302 clinical medicine Stilbenes Food science Biology (General) Spectroscopy media_common Chemistry food and beverages General Medicine Isoflavone Computer Science Applications 030220 oncology & carcinogenesis Biological Product Quercetin Flavonol Ellagic acid Human Drug Polyphenol Coumaric Acids QH301-705.5 media_common.quotation_subject Biological Availability Catalysis Permeability Inorganic Chemistry 03 medical and health sciences Nutraceutical Chlorogenic acid Animals Humans Physical and Theoretical Chemistry Molecular Biology QD1-999 Flavone Biological Products Animal Organic Chemistry Polyphenols Flavones Isoflavones Metabolism Intestinal Absorption Solubility Biopharmaceutical classification system Stilbene Tannins |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 5514, p 5514 (2021) |
Popis: | Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification. |
Databáze: | OpenAIRE |
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