An overview on dietary polyphenols and their biopharmaceutical classification system (Bcs)

Autor: Camilla Tibaldi, Francesca Truzzi, Eros D′Amen, Giovanni Dinelli, Yanxin Zhang
Přispěvatelé: Truzzi F., Tibaldi C., Zhang Y., Dinelli G., D'Amen E.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Flavonols
Bioavailability
LogP
Review
Coumaric Acid
030226 pharmacology & pharmacy
Ferulic acid
chemistry.chemical_compound
0302 clinical medicine
Stilbenes
Food science
Biology (General)
Spectroscopy
media_common
Chemistry
food and beverages
General Medicine
Isoflavone
Computer Science Applications
030220 oncology & carcinogenesis
Biological Product
Quercetin
Flavonol
Ellagic acid
Human
Drug
Polyphenol
Coumaric Acids
QH301-705.5
media_common.quotation_subject
Biological Availability
Catalysis
Permeability
Inorganic Chemistry
03 medical and health sciences
Nutraceutical
Chlorogenic acid
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
Flavone
Biological Products
Animal
Organic Chemistry
Polyphenols
Flavones
Isoflavones
Metabolism
Intestinal Absorption
Solubility
Biopharmaceutical classification system
Stilbene
Tannins
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5514, p 5514 (2021)
Popis: Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.
Databáze: OpenAIRE
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