Surveillance for endometrial cancer in women on tamoxifen: the role of liquid-based endometrial cytology - cytohistological correlation in a population of 168 women
| Autor: | Francesca Castiglione, Anna Maria Buccoliero, Antonio Taddei, Mauro Marchionni, Chiara Francesca Gheri, Duccio Rossi Degl'Innocenti, G. Bargelli, Gianfranco Scarselli, Massimiliano Fambrini, Francesca Garbini, Daniela Moncini, Gian Luigi Taddei, Alfredo Barbetti |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Antineoplastic Agents Hormonal Biopsy Population Breast Neoplasms Endometrium Cytology Medicine Humans education Aged Gynecology Aged 80 and over education.field_of_study business.industry Obstetrics Endometrial cancer Obstetrics and Gynecology Cancer Middle Aged medicine.disease Antiestrogen Endometrial hyperplasia Endometrial Neoplasms Tamoxifen Reproductive Medicine Liquid-based cytology Female business Carcinoma Endometrioid medicine.drug |
| Zdroj: | Gynecologic and obstetric investigation. 65(4) |
| ISSN: | 1423-002X |
| Popis: | Aims: The aim of this study was to evaluate the utility of liquid-based cytology for endometrial surveillance in patients receiving tamoxifen. Methods: One hundred and sixty-eight women scheduled for hysteroscopy were enrolled in the study. The women sequentially underwent hysteroscopy, endometrial cytology and biopsy. Results: Endometrial biopsy only was inadequate in 112 (67%) patients, both endometrial biopsy and cytology were inadequate in 19 (11%) patients, endometrial cytology only was inadequate in 4 (2%) patients, and both endometrial biopsy and cytology were adequate in 33 (20%) patients. Overall, endometrial biopsy was inadequate in 131 (78%) patients and endometrial cytology in 23 (14%) patients. Endometrial cytology provided sufficient material for diagnosis more often than endometrial biopsy (p < 0.05). In the series of 33 patients (20%) in whom both endometrial cytology and biopsy were adequate, there was a 100% correlation between the endometrial cytology and biopsy results. Conclusions: For the first time, this study shows the diagnostic efficacy of liquid-based endometrial cytology in the follow-up of women receiving tamoxifen. It could be applied solely or in conjunction with ultrasonography. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|