Changes in gastrointestinal cell integrity after marathon running and exercise-associated collapse
| Autor: | Oliver R. Gibson, David R. Woods, Edward Walter, Mike Stacey, Neil E. Hill, Iain T Parsons |
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| Rok vydání: | 2021 |
| Předmět: |
Hyperthermia
medicine.medical_specialty Intestinal permeability Sports medicine Physiology business.industry Marathon running Public Health Environmental and Occupational Health General Medicine medicine.disease Endurance training Physiology (medical) Internal medicine Cell integrity Cardiology Medicine Biomarker (medicine) lipids (amino acids peptides and proteins) Orthopedics and Sports Medicine medicine.symptom business Collapse (medical) |
| Zdroj: | European Journal of Applied Physiology. 121:1179-1187 |
| ISSN: | 1439-6327 1439-6319 |
| Popis: | Purpose\ud Endurance exercise and hyperthermia are associated with compromised intestinal permeability and endotoxaemia. The presence of intestinal fatty acid-binding protein (I-FABP) in the systemic circulation suggests intestinal wall damage, but this marker has not previously been used to investigate intestinal integrity after marathon running.\ud \ud Methods\ud Twenty-four runners were recruited as controls prior to completing a standard marathon and had sequential I-FABP measurements before and on completion of the marathon, then at four and 24 h later. Eight runners incapacitated with exercise-associated collapse (EAC) with hyperthermia had I-FABP measured at the time of collapse and 1 hour later.\ud \ud Results\ud I-FABP was increased immediately on completing the marathon (T0; 2593 ± 1373 ng·l−1) compared with baseline (1129 ± 493 ng·l−1; p |
| Databáze: | OpenAIRE |
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