Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant
| Autor: | Sarah Waddun Jannat, Bibi Humayra Khanam, Mohammed Kamrul Hossain, Sayeda Saima Didari, Syeda Rubaiya Afrin, Nawreen Monir Proma, Mohammad Rashedul Islam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
biology
Traditional medicine Cytotoxic Analgesic Phytochemicals Ethyl acetate RM1-950 biology.organism_classification RS1-441 chemistry.chemical_compound Acetic acid Pharmacy and materia medica chemistry Phytochemical In vivo medicine Carbon tetrachloride Araliaceae Macropanax dispermus Antipyretic Therapeutics. Pharmacology Thrombolytic medicine.drug |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2314-7253 |
| Popis: | Background Macropanax dispermus is traditionally used to treat various diseases by ethnic people. The present research reports the pharmacological properties with phytochemical profiling of the crude extracts of M. dispermus leaves (MDML), its n-hexane (MDHL), carbon tetrachloride (MDTL), chloroform (MDCL), ethyl acetate (MDEL), and aqueous (MDAL) fractions, and crude methanol extracts of its stem barks (MDMS). The in vitro thrombolytic activity was done on human erythrocytes whereas the cytotoxic activity was done by brine shrimp lethality assay. The in vivo analgesic activity was examined by acetic acid-induced writhing, tail immersion, and formalin-induced paw licking method. In contrast, antipyretic activity was done by the brewer’s yeast-induced pyrexia method. Results MDHL and MDMS showed 37.05% and 42.21% of significant (p 50 values of 23.15 and 37.11 µg/ml during cytotoxicity test, respectively. In acetic acid writhing method, MDTL and MDEL showed significant (p p p p Conclusion The current research suggests that the plant extracts possess potential thrombolytic, cytotoxic, analgesic, and antipyretic activities. |
| Databáze: | OpenAIRE |
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