Treatment of recurrent epithelial ovarian cancer
| Autor: | Sandro Pignata, Gaetano Facchini, Claudia Marchetti, Carmela Pisano, Giovanni Salvatore Bruni |
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| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Disease RM1-950 Review chemotherapy Internal medicine Recurrent disease Medicine Pharmacology (medical) Epithelial ovarian cancer General Pharmacology Toxicology and Pharmaceutics Chemotherapy Chemical Health and Safety Settore MED/06 - ONCOLOGIA MEDICA business.industry Systemic chemotherapy Mortality rate General Medicine medicine.disease Surgery Settore MED/40 - GINECOLOGIA E OSTETRICIA ovarian cancer Recurrent Ovarian Cancer Therapeutics. Pharmacology business Ovarian cancer Safety Research |
| Zdroj: | Scopus-Elsevier Therapeutics and Clinical Risk Management Therapeutics and Clinical Risk Management, Vol 2009, Iss default, Pp 421-426 (2009) |
| Popis: | Carmela Pisano, Giovanni S Bruni, Gaetano Facchini, Claudia Marchetti, Sandro PignataOncologia Medica, Dipartimento Uro-Ginecologico, Istituto Nazionale Tumori, Napoli, ItalyAbstract: Epidemiologic analysis reveals that the mortality rate from ovarian cancer is continuously decreasing due to the improvement of surgery and chemotherapy. However, the prognosis of ovarian cancer patients is still unsatisfactory overall considering that only 30% of patients are alive after five years. In fact, although surgery and first-line systemic chemotherapy induces complete and partial response in up to 80% of patients with about a 25% pathological complete remission rate, recurrences occur in the majority of patients. The role of surgery in recurrent disease has been recently studied and many patients can receive an optimal secondary cytoreduction. Most of the recurrent patients are subject to a number of treatment regimens that, although palliative in nature, are also able to prolong survival. Important results have been obtained in particular in platinum-sensitive recurrent disease where a platinum-based chemotherapy is able to prolong progression-free survival and overall survival. Overall, our armamentarium for the treatment of progressive or recurrent ovarian cancer is significantly richer than in the past, and in many patients it is possible to achieve our goal of controlling the chronic behavior of the disease.Keywords: ovarian cancer, chemotherapy |
| Databáze: | OpenAIRE |
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