Enhancement of rat liver uridine kinase activity by various metabolic inhibitors
| Autor: | Jiři Veselý, Alois Čihák, Ken R. Harrap |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Orotic acid Azauridine Glutarimide Antineoplastic Agents Thymus Gland Cycloheximide In Vitro Techniques Thioacetamide Biochemistry Uridine kinase chemistry.chemical_compound medicine Animals Carbon Radioisotopes Uridine Pharmacology chemistry.chemical_classification Orotic Acid Antibiotics Antineoplastic biology Cell-Free System Daunorubicin Phosphotransferases Enzyme assay Stimulation Chemical Diet Rats Enzyme Pyrimidines chemistry Liver Puromycin Doxorubicin biology.protein Azacitidine Dactinomycin medicine.drug |
| Zdroj: | Biochemical pharmacology. 23(6) |
| ISSN: | 0006-2952 |
| Popis: | Of 25 compounds tested, eight—namely, 5-azacytidine, gougerotin, cycloheximide, pactamyein, streptovitaein A, adriamyein, daunoruhicin and thioacetamide resulted in the enhancement of liver uridine kinase actiuty in vivo . Puromycin and actinomycin D produced a slight decrease in enzyme activity. With both 5-azaeytidine and cyeloheximide, the enhancement observed was independent of adrenal secretion. Some of the compounds which enhanced hepatic uridine kinase activity 15-azacytidine, cycloheximide and related glutarimide antibioties concomitantly suppressed the activity of the enzyme in the thymus, while daunoruhicin adriamycin and thioacetamide were much less effective in this respect. No relation has been found between the effect of the tested compounds on the incorporation of orotic acid into RNA and the enhanced activity of hepatic uridine kinase. |
| Databáze: | OpenAIRE |
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