Multiplexed immunosensors for point-of-care diagnostic applications
| Autor: | Bruno Gil Rosa, Oluwatomi E. Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A. Crone, Loren P. Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J. Sharp, Bing Li |
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| Přispěvatelé: | UK DRI Ltd |
| Rok vydání: | 2021 |
| Předmět: |
Immunoassay
1007 Nanotechnology Bioinformatics Point-of-Care Systems Progressive disease Biomedical Engineering Biophysics Point-of-care detection Reproducibility of Results Multiplexed immunosensors General Medicine Biosensing Techniques Electrochemical Techniques 0903 Biomedical Engineering Point-of-Care Testing Protein biomarkers Electrochemistry 0301 Analytical Chemistry Biotechnology |
| Zdroj: | Biosensorsbioelectronics. 203 |
| ISSN: | 1873-4235 |
| Popis: | Accurate, reliable, and cost-effective immunosensors are clinically important for the early diagnosis and monitoring of progressive diseases, and multiplexed sensing is a promising strategy for the next generation of diagnostics. This strategy allows for the simultaneous detection and quantification of multiple biomarkers with significantly enhanced reproducibility and reliability, whilst requiring smaller sample volumes, fewer materials, and shorter average analysis time for individual biomarkers than individual tests. In this opinionated review, we compare different techniques for the development of multiplexed immunosensors. We review the state-of-the-art approaches in the field of multiplexed immunosensors using electrical, electrochemical, and optical methods. The barriers that prevent translating this sensing strategy into clinics are outlined together with the potential solutions. We also share our vision on how multiplexed immunosensors will continue their evolution in the coming years. |
| Databáze: | OpenAIRE |
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