Hormone receptors and cyclic nucleotide metabolism in cancer cells
| Autor: | V. P. Michelangeli, Helen Boyd, D. Atkins, Hunt Nh, T. J. Martin, Morag Ellison |
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| Rok vydání: | 1976 |
| Předmět: |
Adenoma
Calcitonin medicine.medical_specialty Carcinoma Hepatocellular Kidney Cortex Endocrinology Diabetes and Metabolism Renal cortex Adenylate kinase Receptors Cell Surface Biology Adenocarcinoma Cyclase Parathyroid Glands Endocrinology Internal medicine Neoplasms medicine Cyclic AMP Animals Humans Cells Cultured Methyldimethylaminoazobenzene Hydroxycholecalciferols Cell Membrane Liver Neoplasms Kidney Neoplasms Rats medicine.anatomical_structure Parathyroid Neoplasms Hormone receptor Parathyroid hormone secretion Parathyroid gland Nucleotides Cyclic Cyclase activity Adenylyl Cyclases |
| Zdroj: | Clinical endocrinology. |
| ISSN: | 0300-0664 |
| Popis: | The possibility of a relationship between cyclic AMP formation and metabolic processes in tumours has been investigated. Changes in basal activity and hormone-responsiveness of adenylate cyclase were demonstrated in plasma membranes and intact cells from pre-cancerous liver of rats fed a diet containing the carcinogen 3'-methyl-4-dimethylaminoazobenzene. Basal adenylate cyclase activity in hyperplastic parathyroid gland membranes was 200% higher than that in parathyroid adenoma membranes, corresponding with their relative rates of parathyroid hormone secretion in vitro. Membrane adenylate cyclase activity in hypernephromas was consistently 100--300% higher than in adjacent human renal cortex. Furthermore the adenylate cyclase activity of the tumour membranes was not influenced by a wide range of hormones which were effective stimulants in 'normal' renal cortex membranes. Conversion of 25-hydroxycholecalciferol to 1,25-dihydrocholecalciferol could not be demonstrated in either hypernephroma or adjacent renal cortical tissue. However, three of the four hypernephromas tested secreted a bone-resorbing factor. Cyclic AMP formation was increased by salmon, human and porcine calcitonins in both plasma membranes and intact cells from a poorly differentiated epidermoid cell carcinoma which was itself secreting calcitonin in culture. This phenomenon might be related to a feedback regulation of calcitonin production in this cell line. The observations are consistent with the concept of a relationship between cyclic AMP formation and certain metabolic functions (e.g. hormone production) in tumour cells. |
| Databáze: | OpenAIRE |
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