Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem

Autor:	Armin Mooranian, Susbin Raj Wagle, Daniel Walker, Jacqueline Chester, Corina Mihaela Ionescu, Melissa Jones, Bozica Kovacevic, Hani Al-Salami, Edan Johnston, Thomas Foster, Momir Mikov
Rok vydání:	2022
Předmět:	Materials science Polymers Drug Compounding Pharmaceutical Science Nanotechnology Cell Encapsulation Pharmaceutical formulation Lab-on-a-chip law.invention Bile Acids and Salts Excipients law Lab-On-A-Chip Devices Microsystem Cell encapsulation Bioartificial Organ
Zdroj:	Therapeutic Delivery. 13:51-65
ISSN:	2041-6008 2041-5990
DOI:	10.4155/tde-2021-0067
Popis:	Microencapsulation of formulation designs further expands the field and offers the potential for use in developing bioartificial organs via cell encapsulation. Combining formulation design and encapsulation requires ideal excipients to be determined. In terms of cell encapsulation, an environment which allows growth and functionality is paramount to ensuring cell survival and incorporation into a bioartificial organ. Hence, excipients are examined for both individual properties and benefits, and compatibility with encapsulated active materials. Polymers are commonly used in microencapsulation, offering protection from the immune system. Bile acids are emerging as a tool to enhance delivery, both biologically and pharmaceutically. Therefore, this review will focus on bile acids and polymers in formulation design via microencapsulation, in the field of bioartificial organ development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15561950755127b273e5625724bc842 https://doi.org/10.4155/tde-2021-0067 Zobrazit plný text záznamu