Use of fluorodeoxyglucose positron emission tomography for diagnosis of bleomycin-induced pneumonitis in Hodgkin lymphoma

Autor:	Burhan Ferhanoglu, Murat Ozbalak, Okan Falay, Onur Demirkol, Serdar Örnek, Erman Öztürk, Yasemin Bolukbasi, Mustafa Çetiner, Terman Gümüş
Rok vydání:	2017
Předmět:	Adult Male Cancer Research medicine.medical_specialty Pulmonary toxicity Bleomycin Pulmonary function testing Fluorodeoxyglucose positron emission tomography 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Medicine Humans Pneumonitis Aged Neoplasm Staging Retrospective Studies Aged 80 and over PET-CT Antibiotics Antineoplastic business.industry Hematology Pneumonia respiratory system Middle Aged medicine.disease Combined Modality Therapy Hodgkin Disease respiratory tract diseases carbohydrates (lipids) Oncology chemistry 030220 oncology & carcinogenesis Positron-Emission Tomography Hodgkin lymphoma Female Radiology business 030215 immunology
Zdroj:	Leukemialymphoma. 58(5)
ISSN:	1029-2403
Popis:	Bleomycin is an antineoplastic agent causing fatal pulmonary toxicity. Early diagnosis of bleomycin-induced pneumonitis is crucial to prevent irreversible damage. Pulmonary function tests are unreliable for identifying risk of bleomycin toxicity. Fluorodeoxyglucose PET/CT scanning can reveal inflammation secondary to pneumonitis but is not sufficiently specific for diagnosis. We retrospectively analyzed scans from 77 patients with Hodgkin lymphoma (median age 41 years, mean bleomycin dose 134 mg) to evaluate bleomycin-induced pneumonitis. We identified 13 patients with abnormal lung uptake of fluorodeoxyglucose. Tracer activity was predominantly diffuse, bilateral, in the lower lobes and subpleural areas. Interim scanning during treatment revealed pneumonitis in eight of 13 patients (asymptomatic in six). One asymptomatic patient died of bleomycin toxicity. For remaining 12 patients, bleomycin was discontinued and methylprednisolone given, all showed resolution of the pneumonitis. These findings suggest that routine interim or end-of-treatment FDG-PET/CT scanning could be beneficial for alerting clinicians to asymptomatic bleomycin-induced toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1555080d6f52e6b7e18d635ffb8c211 https://pubmed.ncbi.nlm.nih.gov/28185528 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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