Impact of maternal serum levels of Visfatin, AFP, PAPP-A, sFlt-1 and PlGF at 11–13 weeks gestation on small for gestational age births
| Autor: | J Fryze, Stefanie Frölich, Markus Schmidt, Angela Köninger, Alexandra Gellhaus, Rainer Kimmig, Börge Schmidt, Cahit Birdir |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy-associated plasma protein A Medizin Enzyme-Linked Immunosorbent Assay Gestational Age 030204 cardiovascular system & hematology Ultrasonography Prenatal Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Interquartile range Internal medicine Odds Ratio medicine Humans Pregnancy-Associated Plasma Protein-A Nicotinamide Phosphoribosyltransferase Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Smoking Infant Newborn Membrane Proteins Obstetrics and Gynecology Gestational age Odds ratio medicine.disease Confidence interval Pregnancy Trimester First Logistic Models Endocrinology ROC Curve Case-Control Studies Infant Small for Gestational Age Pediatrics Perinatology and Child Health Small for gestational age Gestation Female business Biomarkers |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 30:629-634 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Investigating potential value of maternal serum Visfatin, sFlt-1, PlGF, AFP, PAPP-A levels at first trimester for prediction of small for gestational age (SGA) at birth.Measurements were performed in 20 SGA and 65 control cases. Logistic regression analysis adjusted for age and weeks of pregnancy at data collection was performed to estimate odds ratios (OR), 95% confidence intervals (95% CI) and p values separately for each potential predictor. A multiple regression model was used to assess the impact of all the promising predictors adjusted for each other. Receiver operating characteristic (ROC) analysis was used to indicate the ability to discriminate between SGA cases and controls.There was an association of serum PlGF levels (OR 0.53 per interquartile range [IQR] increase in PlGF; 95% CI 0.24-1.16), sFlt-1/PlGF ratio (OR 1.42 per IQR increase in sFlt-1/PlGF; 95% CI 1.03-1.96), serum Visfatin levels (OR 0.31 per IQR increase in Visfatin; 95% CI 0.10-0.95) and smoking (OR 4.24; 95% CI 1.10-16.37) with SGA at birth.Associations between SGA and lower PlGF, Visfatin levels as well as increased sFlt-1/PlGF ratio and smoking status were detected which may contribute to predict SGA. |
| Databáze: | OpenAIRE |
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