Serum Levels of the Adipokine Progranulin Depend on Renal Function
| Autor: | J Richter, Ulrike Lossner, Denise Focke, Anette Bachmann, Jürgen Kratzsch, Peter Kovacs, Joachim Beige, Matthias Anders, Susan Kralisch, Michael Stumvoll, Matthias Blüher, Mathias Fasshauer, Thomas Ebert, Ingolf Bast |
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| Rok vydání: | 2013 |
| Předmět: |
Advanced and Specialized Nursing
Kidney medicine.medical_specialty Adiponectin business.industry Endocrinology Diabetes and Metabolism Adipokine Renal function urologic and male genital diseases medicine.disease medicine.anatomical_structure Endocrinology Insulin resistance Diabetes mellitus Internal medicine mental disorders Internal Medicine medicine Metabolic syndrome Pathophysiology/Complications business Original Research Kidney disease |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE Progranulin has recently been introduced as a novel adipokine inducing insulin resistance and obesity. In the current study, we investigated renal elimination, as well as association of the adipokine with markers of the metabolic syndrome. RESEARCH DESIGN AND METHODS Progranulin serum levels were quantified by enzyme-linked immunosorbent assay and correlated to anthropometric and biochemical parameters of renal function and glucose and lipid metabolism, as well as inflammation, in 532 patients with stages 1–5 of chronic kidney disease (CKD). RESULTS Median serum progranulin levels adjusted for age, sex, and BMI were significantly different between CKD stages with highest values detectable in stage 5 (stage 1, 58.3 µg/L; stage 2, 63.0 µg/L; stage 3, 65.4 µg/L; stage 4, 68.8 µg/L; and stage 5, 90.6 µg/L). Furthermore, CKD stage was the strongest independent predictor of circulating progranulin in our cohort. In addition, high-sensitivity interleukin-6 and adiponectin remained significantly and independently correlated with the adipokine. CONCLUSIONS We demonstrate that progranulin serum levels increase with deteriorating renal function. These findings are in accordance with the hypothesis that renal clearance is a major elimination route for circulating progranulin. Furthermore, the adipokine is positively and independently associated with markers of inflammation and adiponectin. |
| Databáze: | OpenAIRE |
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