In vitro alterations in human fibroblast behavior secondary to silicone polymers
| Autor: | Martin C. Robson, Patricia J. Brown, William B. Riley, Robert L. McCauley, Rudolph A. Juliano, Michael J. Evans |
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| Rok vydání: | 1990 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Contracture Cell Silicones complex mixtures Cell Line chemistry.chemical_compound Silicone Hemocytometer medicine Humans Fibroblast Skin Viral matrix protein Chemistry Endoplasmic reticulum technology industry and agriculture Biomaterial Prostheses and Implants Fibroblasts equipment and supplies In vitro Surgery Cell biology stomatognathic diseases medicine.anatomical_structure Silicone Elastomers |
| Zdroj: | Journal of Surgical Research. 49:103-109 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(90)90118-l |
| Popis: | The etiology of fibrous capsular contractures in patients with silicone prostheses is unclear. However, cellular responses to the silicone polymers of the prostheses have not been examined. The exposure of human dermal fibroblasts to the components of the silicone gel prosthesis results in a significant change in cellular configuration and a progressive reduction in cell proliferation as determined by total matrix protein assays and hemocytometer cell counts. Transmission electron microscopy, however, documents a twofold increase in the rough endoplasmic reticulum when cells are exposed to the silicone gel. These findings suggest significant alterations in the behavior of human fibroblast subpopulations in response to silicone polymers. |
| Databáze: | OpenAIRE |
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