The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
| Autor: | Ruben Zamora, L Hermus, Timothy R. Billiar, Yoram Vodovotz, Ali Ghuma, Rajaie Namas, David O. Okonkwo |
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| Rok vydání: | 2009 |
| Předmět: |
0301 basic medicine
Chemokine Traumatic brain injury lcsh:Medicine Inflammation Review Article Nitric oxide 03 medical and health sciences hemorrhagic shock chemistry.chemical_compound Immune system Cerebrospinal fluid CEREBROSPINAL-FLUID TRANSLATIONAL SYSTEMS BIOLOGY Medicine ORGAN DYSFUNCTION SYNDROME NITRIC-OXIDE 030102 biochemistry & molecular biology biology business.industry traumatic brain injury Regeneration (biology) lcsh:R NECROSIS-FACTOR-ALPHA HEMORRHAGIC-SHOCK systems biology CYTOKINE PRODUCTION General Medicine IN-SILICO medicine.disease REDUCED MATHEMATICAL-MODEL 030104 developmental biology trauma Traumatic injury chemistry Immunology biology.protein medicine.symptom business CLINICAL-TRIALS |
| Zdroj: | Libyan Journal of Medicine; Vol 4, No 3 (2009); 97-103 Libyan Journal of Medicine, Vol 4, Iss 3, Pp 136-148 (2009) The Libyan Journal of Medicine Libyan Journal of Medicine; Vol 4, No 3 (2009) |
| ISSN: | 1819-6357 1993-2820 |
| DOI: | 10.4176/090325 |
| Popis: | Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may result in death. Inflammation describes a coordinated series of molecular, cellular, tissue, organ, and systemic responses that drive the pathology of various diseases including T/HS and traumatic brain injury (TBI). Inflammation is a finely tuned, dynamic, highly-regulated process that is not inherently detrimental, but rather required for immune surveillance, optimal post-injury tissue repair, and regeneration. The inflammatory response is driven by cytokines and chemokines and is partially propagated by damaged tissue-derived products (Damage-associated Molecular Patterns; DAMP’s). DAMPs perpetuate inflammation through the release of pro-inflammatory cytokines, but may also inhibit anti-inflammatory cytokines. Various animal models of T/HS in mice, rats, pigs, dogs, and non-human primates have been utilized in an attempt to move from bench to bedside. Novel approaches, including those from the field of systems biology, may yield therapeutic breakthroughs in T/HS and TBI in the near future. Key words: Trauma, Hemorrhagic Shock, Taumatic Brain Injury, Inflammation, Systems Biology |
| Databáze: | OpenAIRE |
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