A Nonexercise Prediction of Peak Oxygen Uptake for Patients With Cardiovascular Disease

Autor: James E, Peterman, Ross, Arena, Jonathan, Myers, Philip A, Ades, Amanda R, Bonikowske, Matthew P, Harber, Susan, Marzolini, Patrick D, Savage, Ray W, Squires, Carl J, Lavie, Leonard A, Kaminsky
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cardiopulmonary Rehabilitation and Prevention. 43:115-121
ISSN: 1932-7501
DOI: 10.1097/hcr.0000000000000722
Popis: Nonexercise predictions of peak oxygen uptake (V˙o2peak) are used clinically, yet current equations were developed from cohorts of apparently healthy individuals and may not be applicable to individuals with cardiovascular disease (CVD). Our purpose was to develop a CVD-specific nonexercise prediction equation for V˙o2peak.Participants were from the Fitness Registry and Importance of Exercise International Database (FRIEND) with a diagnosis of coronary artery bypass surgery (CABG), myocardial infarction (MI), percutaneous coronary intervention (PCI), or heart failure (HF) who met maximal effort criteria during a cardiopulmonary exercise test (n = 15 997; 83% male; age 63.1 ± 10.4 yr). The cohort was split into development (n = 12 798) and validation groups (n = 3199). The prediction equation was developed using regression analysis and compared with a previous equation developed on a healthy cohort.Age, sex, height, weight, exercise mode, and CVD diagnosis were all significant predictors of V˙o2peak. The regression equation was:V˙o2peak (mL · kg-1 · min-1) = 16.18 - (0.22 × age [yr]) + (3.63 × sex [male = 1; female = 0]) + (0.14 × height [cm]) - (0.12 × weight [kg]) + (3.62 × mode [treadmill = 1; cycle = 0]) - (2.70 × CABG [yes = 1, no = 0]) - (0.31 × MI [yes = 1, no = 0]) + (0.37 × PCI [yes = 1, no = 0]) - (4.47 × HF [yes = 1, no = 0]). Adjusted R2 = 0.43; SEE = 4.75 mL · kg-1 · min-1.Compared with measured V˙o2peak in the validation group, percent predicted V˙o2peak was 141% for the healthy cohort equation and 100% for the CVD-specific equation.The new equation for individuals with CVD had lower error between measured and predicted V˙o2peak than the healthy cohort equation, suggesting population-specific equations are needed for predicting V˙o2peak; however, errors associated with nonexercise prediction equations suggest V˙o2peak should be directly measured whenever feasible.
Databáze: OpenAIRE