Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19
| Autor: | Ana Rodriguez, Kun Qian, Marisol Zuniga, Jill P. Buyon, Robert R. Clancy, Nubia Catalina Tovar, Paolo Cotzia, Maria Fernanda Yasnot-Acosta, Kelly A. Crotty, Claudia Gomes, David C. Lee, Kimon Argyropoulos, Lawrence Hsu Lin, Huilin Li, Peter M. Izmirly |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Erythrocytes Health Toxicology and Mutagenesis Phosphatidylserines Plant Science Severity of Illness Index Biochemistry Genetics and Molecular Biology (miscellaneous) Pathogenesis chemistry.chemical_compound Antigen Severity of illness Humans Medicine Research Articles Aged Autoantibodies Retrospective Studies Aged 80 and over Ecology biology SARS-CoV-2 business.industry Autoantibody COVID-19 Retrospective cohort study DNA Phosphatidylserine Middle Aged Prognosis Coagulation chemistry Antibodies Antinuclear Immunology biology.protein Female Antibody business Biomarkers Research Article |
| Zdroj: | Life Science Alliance |
| ISSN: | 2575-1077 |
| DOI: | 10.26508/lsa.202101180 |
| Popis: | COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease. High levels of autoimmune antibodies are observed in COVID-19 patients but their specific contribution to disease severity and clinical manifestations remains poorly understood. We performed a retrospective study of 115 COVID-19 hospitalized patients with different degrees of severity to analyze the generation of autoimmune antibodies to common antigens: a lysate of erythrocytes, the lipid phosphatidylserine (PS) and DNA. High levels of IgG autoantibodies against erythrocyte lysates were observed in a large percentage (up to 36%) of patients. Anti-DNA and anti-PS antibodies determined upon hospital admission correlated strongly with later development of severe disease, showing a positive predictive value of 85.7% and 92.8%, respectively. Patients with positive values for at least one of the two autoantibodies accounted for 24% of total severe cases. Statistical analysis identified strong correlations between anti-DNA antibodies and markers of cell injury, coagulation, neutrophil levels and erythrocyte size. Anti-DNA and anti-PS autoantibodies may play an important role in the pathogenesis of COVID-19 and could be developed as predictive biomarkers for disease severity and specific clinical manifestations. |
| Databáze: | OpenAIRE |
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