Morphometric analysis of the thymus of puppies infected with the Snyder Hill Strain of canine distemper virus

Autor:	A.S. Martins, Luciana Moro, F.G.A. Santos, C. Alves, Anilton Cesar Vasconcelos, Paula Peixoto Campos, J.E.S. Nunes, H L Del Puerto
Rok vydání:	2006
Předmět:	Pathology medicine.medical_specialty immunosuppression General Veterinary biology puppy Canine distemper viruses apoptosis canine distemper virus medicine.disease Virology Virus Nucleoprotein immunology Atrophy thymus Puppy Apoptosis biology.animal Parenchyma medicine Immunohistochemistry
Zdroj:	Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.58 n.4 2006 Arquivo brasileiro de medicina veterinária e zootecnia Universidade Federal de Minas Gerais (UFMG) instacron:UFMG
ISSN:	0102-0935
Popis:	The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic index/field than negative control (not inoculated) puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14cfc9635a878cfd4b82587db7ac195 https://doi.org/10.1590/s0102-09352006000400004 Zobrazit plný text záznamu