In vivo antiplasmodial activity of Bombax buonopozense root bark aqueous extract in mice infected by Plasmodium berghei
| Autor: | Essien Augustine Dick, Ezeonu Chinonyelum Thecla, Nwobodo Ndubuisi Nwobodo, Asika Ebere Chile, Akuodor Godwin Christian, Chilaka Kingsley Chimsorom, Nwachukwu Daniel Ckukwu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology Traditional medicine business.industry 030231 tropical medicine Bombax General Medicine 030108 mycology & parasitology biology.organism_classification complex mixtures Acute toxicity 03 medical and health sciences 0302 clinical medicine Bombax buonopozense In vivo Chloroquine visual_art Immunology visual_art.visual_art_medium Medicine Plasmodium berghei Bark Antimalarial Agent business medicine.drug |
| Zdroj: | Journal of Traditional Chinese Medicine. 37:431-435 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(17)30148-6 |
| Popis: | To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous extract.The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in mice.The findings of this study revealed significant (P0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/kg.Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents. |
| Databáze: | OpenAIRE |
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