Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis
| Autor: | Pierre Bouche, Michel Dib, Gilbert Ben Simon, Lucette Lacomblez, Vincent Meininger, Nina Mombo, Anne Rozier, Nicole Baumann, Amena Ben Younes-Chennoufi, Robert K. Yu |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Igm antibody Immunology Enzyme-Linked Immunosorbent Assay medicine.disease_cause Autoimmunity medicine Immunology and Allergy Humans Amyotrophic lateral sclerosis biology Globosides business.industry Amyotrophic Lateral Sclerosis Middle Aged medicine.disease Titer Neurology Immunoglobulin M Polyclonal antibodies biology.protein Female Neurology (clinical) Antibody business Multifocal motor neuropathy |
| Zdroj: | Journal of neuroimmunology. 57(1-2) |
| ISSN: | 0165-5728 |
| Popis: | We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology. |
| Databáze: | OpenAIRE |
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