Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study
| Autor: | Kento Fukumitsu, Takanari Kitazono, Shunsuke Yamada, Atsumi Harada, Satoru Shichijo, Mika Kondo, Kazuhiko Tsuruya, Yutaro Hirashima, Taro Kamimura, Toshiaki Nakano, Seishi Aihara, Hideaki Oka |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Lidocaine medicine.medical_treatment 030232 urology & nephrology Pain relief Vascular access Pain 030204 cardiovascular system & hematology Placebo Single Center 03 medical and health sciences 0302 clinical medicine Double-Blind Method Renal Dialysis medicine Humans In patient Anesthetics Local Lidocaine Prilocaine Drug Combination Aged Cross-Over Studies business.industry Hematology Middle Aged Crossover study Treatment Outcome Nephrology Anesthesia Female Hemodialysis business Vascular Access Devices medicine.drug |
| Zdroj: | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis TherapyREFERENCES. 24(1) |
| ISSN: | 1744-9987 |
| Popis: | Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT-associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. The present study was performed to determine whether lidocaine-propitocain cream, a eutectic mixture of local anesthetics (EMLA), effectively reduces VAIVT-associated pain in patients undergoing hemodialysis. This placebo-controlled, double-blind, crossover study was conducted in a single center. Among 210 patients who underwent a total of 437 VAIVT procedures from August 2017 to June 2018, 30 patients were randomly allocated to either the EMLA-placebo arm or placebo-EMLA arm at the time of VAIVT. EMLA application significantly reduced the visual analog scale score compared with placebo (47.0 ± 21.1 vs. 68.6 ± 20.7 mm, respectively; P < 0.05). EMLA is a safe and effective treatment for relief of VAIVT-associated pain in patients undergoing hemodialysis. |
| Databáze: | OpenAIRE |
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