The first report of familial adult T-cell leukemia/lymphoma in Argentina
| Autor: | Virginia Prates, Jorge Milone, Javier Bordone, Belén Bouzas, Juan Napal, Marisa Cobos |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Cancer Research Pediatrics medicine.medical_specialty Argentina Asymptomatic Adult T-cell leukemia/lymphoma Serology Immunophenotyping Nuclear Family immune system diseases hemic and lymphatic diseases Medicine Humans Leukemia-Lymphoma Adult T-Cell Family history Human T-lymphotropic virus 1 business.industry Hematology Middle Aged medicine.disease Lymphoma Leukemia Oncology Immunology Female CD5 medicine.symptom business |
| Zdroj: | Leukemialymphoma. 37(1-2) |
| ISSN: | 1042-8194 |
| Popis: | Here we describe two Caucasian brothers who developed adult T-cell leukemia/lymphoma (ATLL), within a short period of time. These two patients have never left Argentina. Their parents are dead and according to the family history it is possible that the mother may have been affected by spastic paraparesis. The daughters reported that their mother had suffered from increasing difficulty in walking for many years which finally made it impossible for to her walk. There are no other data to support the presumptive diagnosis. One of the patients presented with acute disease while the other had a lymphoma type disorder. Both were positive for HTLV 1. The first patient died with disease progression ten months after diagnosis and the second is in partial remission 13 months after diagnosis. Immunophenotyping showed CD4+, CD5+, CD3+, CD2+, CD8 (-). Two asymptomatic brothers with positive HTLV 1 serology were detected. This is the first family case that has been reported in Argentina. |
| Databáze: | OpenAIRE |
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