Protective effect of ω-3 polyunsaturated fatty acids (PUFA) on sodium nitrite induced nephrotoxicity and oxidative damage in rat kidney
| Autor: | Sheeba Khan, Ahad N.K. Yusufi, Sara Anees Khan, Md. Wasim Khan, N. A. Arivarasu, Shubha Priyamvada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
medicine.medical_treatment Phosphate transport Medicine (miscellaneous) Pharmacology Carbohydrate metabolism Sodium nitrite Fish oil medicine.disease_cause Nephrotoxicity chemistry.chemical_compound medicine TX341-641 Blood urea nitrogen chemistry.chemical_classification Nutrition and Dietetics Chemistry Nutrition. Foods and food supply Brush border membrane Biochemistry Oxidative stress Flaxseed oil Food Science Polyunsaturated fatty acid |
| Zdroj: | Journal of Functional Foods, Vol 5, Iss 2, Pp 956-967 (2013) |
| ISSN: | 1756-4646 |
| Popis: | Sodium nitrite (SNT) widely used as a curative agent in meat processing industry possesses cell-transforming mutagenic and cytogenic properties. Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) has been shown to reduce the severity of certain types of cancers, cardiovascular and renal diseases. The present study examined whether feeding of fish oil (FO)/flaxseed oil (FXO) has protective effect against SNT-induced toxicity. SNT significantly altered the activities of serum creatinine (Crt), blood urea nitrogen (BUN), metabolic and brush border membrane (BBM) enzymes. SNT caused significant imbalances in the antioxidant system associated with increased lipid peroxidation (LPO). Feeding of FO and FXO with SNT ameliorated the changes in various parameters caused by SNT. Nephrotoxicity parameters lowered and enzyme activities of carbohydrate metabolism, BBM and radioactively labeled inorganic phosphate (32Pi) transport were improved to near control values. The results of the present study suggest that ω-3 PUFA-enriched FO and FXO from sea-foods and plant sources respectively are similarly effective in reducing SNT-induced nephrotoxicity and oxidative damage. |
| Databáze: | OpenAIRE |
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