Bronchial Responsiveness to Dry Air Hyperventilation in Smokers May Predict Decline in Airway Status Using Indirect Methods
| Autor: | Susanne Ekedahl, Peter Blomstrand, Birgitta Schmekel |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
Time Factors Vital Capacity Tobacco smoke Risk Factors Forced Expiratory Volume Surveys and Questionnaires Odds Ratio Hyperventilation Respiratory system Lung Resonant frequency Impulse oscillometry medicine.diagnostic_test Smoking Isocapnic hyperventilation of dry air Middle Aged respiratory system Prognosis medicine.anatomical_structure Bronchial hyperresponsiveness Anesthesia Disease Progression Female Bronchoconstriction Bronchial Hyperreactivity medicine.symptom Spirometry Pulmonary and Respiratory Medicine Risk Assessment Article Predictive Value of Tests Oscillometry medicine Humans Respiratory sounds Aged Respiratory Sounds business.industry medicine.disease respiratory tract diseases Logistic Models Cough Case-Control Studies Multivariate Analysis business Follow-Up Studies |
| Zdroj: | Lung |
| ISSN: | 0341-2040 |
| DOI: | 10.1007/s00408-012-9448-y |
| Popis: | Background Disabling respiratory symptoms and rapid decline of lung function may occur in susceptible tobacco smokers. Bronchial hyperresponsiveness (BHR) elicited by direct challenge methods predicts worse lung function outcomes. The aim of this study was to evaluate whether BHR to isocapnic hyperventilation of dry air (IHDA) was associated with rapid deterioration in airway status and respiratory symptoms. Methods One hundred twenty-eight smokers and 26 age- and sex-matched healthy individuals with no history of smoking were investigated. All subjects completed a questionnaire. Spirometry and impulse oscillometry (IOS) measurements were recorded before and after 4 min of IHDA. The tests were repeated after 3 years in 102 smokers and 11 controls. Results Eighty-five smokers (66 %) responded to the challenge with a ≥2.4-Hz increase in resonant frequency (Fres), the cutoff limit defining BHR, as recorded by IOS. They had higher Fres at baseline compared to nonresponding smokers [12.8 ± 3.2 vs. 11.5 ± 3.4 Hz (p |
| Databáze: | OpenAIRE |
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