Roles and regulation of phospholipid scramblases
| Autor: | Kiah Bowers, Arielle Sharp, Meera Nanjundan, Karthik M. Kodigepalli |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
Phospholipid scramblase PL scramblase Transmembrane protein 16 Biophysics Autoimmunity Apoptosis Phosphatidylserines Biology Biochemistry Cell membrane Extracellular matrix protein 1 chemistry.chemical_compound Structural Biology Scott syndrome Phospholipid transfer protein Viral replication Genetics medicine XK-related protein Animals Humans Phospholipid Transfer Proteins education Molecular Biology Protein kinase C Cancer Regulation of gene expression education.field_of_study Cell Membrane Bacterial protection Cell Biology Phosphatidylserine Blood Coagulation Disorders medicine.disease Cell biology medicine.anatomical_structure chemistry Cancer research |
| Zdroj: | FEBS Letters. 589:3-14 |
| ISSN: | 1873-3468 0014-5793 |
| Popis: | Phospholipid scramblase activity is involved in the collapse of phospholipid (PL) asymmetry at the plasma membrane leading to externalization of phosphatidylserine. This activity is crucial for initiation of the blood coagulation cascade and for recognition/elimination of apoptotic cells by macrophages. Efforts to identify gene products associated with this activity led to the characterization of PL scramblase (PLSCR) and XKR family members which contribute to phosphatidylserine exposure in response to apoptotic stimuli. Meanwhile, TMEM16 family members were identified to externalize phosphatidylserine in response to elevated calcium in Scott syndrome platelets, which is critical for activation of the coagulation cascade. Herein, we report their mechanisms of gene regulation, molecular functions independent of their scrambling activity, and their potential roles in pathogenic conditions. |
| Databáze: | OpenAIRE |
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