Structural and functional changes to the retina and optic nerve following panretinal photocoagulation over a 2-year time period
| Autor: | Cindy M.L. Hutnik, Tom G. Sheidow, Phil Hooper, Subrata Chakrabarti, Richard Filek, D K Varma, William Hodge, L Heckler, John R. Gonder |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Retinal Ganglion Cells medicine.medical_specialty Visual acuity genetic structures Nerve fiber layer Visual Acuity Glaucoma Retina Neuro-ophthalmology 03 medical and health sciences 0302 clinical medicine Nerve Fibers Ophthalmology medicine Humans Macula Lutea Aged Analysis of Variance Diabetic Retinopathy Laser Coagulation business.industry Optic Nerve Diabetic retinopathy Middle Aged medicine.disease eye diseases Visual field 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Optic nerve Clinical Study Female sense organs medicine.symptom Visual Fields business Tomography Optical Coherence |
| Zdroj: | Eye (London, England). 31(8) |
| ISSN: | 1476-5454 |
| Popis: | PurposeTo evaluate long-term structural and functional changes to the retina and optic nerve following panretinal photocoagulation (PRP) in diabetic retinopathy (DR) patients.MethodsParticipants were patients with DR requiring PRP and control patients with DR not requiring PRP. The Heidelberg retinal tomography (HRT) and optical coherence tomography (OCT) were performed to analyze the optic nerve and macula. Best-corrected visual acuity (BCVA) and visual field (VF) testing were done to measure central and peripheral vision. Wide-field fluorescein angiogram was performed to monitor the progression of diabetic ischemia. The primary outcome measure was to determine the degree of retinal and optic nerve changes before and after PRP.ResultsThere was a non-significant thickening of the macula and retinal nerve fiber layer at 6 months post laser that recovered by 24 months. Mean perfused ratio was significantly increased (P=0.02) at 12 and 24 months post laser. Independently grading patient stereophotographs, grader 1 indicated there was a non-significant increase in cup to disk ratio post laser, while grader 2 indicated a significant increase at 6 (P=0.04), 12 (P=0.02), and 24 months (P=0.005). There was a significant VF decrease (P≤0.02) at 12 and 24 months post laser with BCVA showing a non-significant trend of deteriorating results.ConclusionDespite an improvement in peripheral perfusion, there was a significant progressive decline of peripheral VF over the study period. Clinical grading of the optic nerve was more unreliable following PRP, despite the absence of significant morphological changes as detected by the OCT and HRT. |
| Databáze: | OpenAIRE |
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