The respiratory physiome: clustering based on a comprehensive lung function assessment in patients with COPD
| Autor: | Daisy J.A. Janssen, Lowie E.G.W. Vanfleteren, Ingrid M. L. Augustin, Emiel F.M. Wouters, Martijn A. Spruit, Swetlana Gaffron, Sarah Houben-Wilke, Frits M.E. Franssen |
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| Přispěvatelé: | Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: MA Longziekten (3) |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_treatment lcsh:Medicine Pulmonary Disease Chronic Obstructive 0302 clinical medicine Diffusing capacity Medicine 030212 general & internal medicine Respiratory system lcsh:Science Lung COPD Multidisciplinary Chronic Obstructive/physiopathology medicine.diagnostic_test VALUES Middle Aged Respiratory Function Tests Pulmonary Disease Chronic Obstructive/physiopathology Cardiology Arterial blood SEX Female medicine.symptom REHABILITATION Spirometry medicine.medical_specialty Exercise intolerance OBSTRUCTIVE PULMONARY-DISEASE VALIDATION CAPACITY Pulmonary Disease 03 medical and health sciences AGE Internal medicine Humans Plethysmograph Pulmonary rehabilitation EXERCISE INTOLERANCE Aged business.industry lcsh:R Lung/physiopathology STANDARDIZATION SPIROMETRY medicine.disease respiratory tract diseases Mood 030228 respiratory system lcsh:Q business |
| Zdroj: | PLOS ONE, 13(9):e0201593. Public Library of Science PLoS ONE, Vol 13, Iss 9, p e0201593 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Background While spirometry and particularly airflow limitation is still considered as an important tool in therapeutic decision making, it poorly reflects the heterogeneity of respiratory impairment in chronic obstructive pulmonary disease (COPD). The aims of this study were to identify pathophysiological clusters in COPD based on an integrated set of standard lung function attributes and to investigate whether these clusters can predict patient-related outcomes and differ in clinical characteristics. Methods Clinically stable COPD patients referred for pulmonary rehabilitation underwent an integrated assessment including clinical characteristics, dyspnea score, exercise performance, mood and health status, and lung function measurements (post-bronchodilator spirometry, body plethysmography, diffusing capacity, mouth pressures and arterial blood gases). Self-organizing maps were used to generate lung function based clusters. Results Clustering of lung function attributes of 518 patients with mild to very severe COPD identified seven different lung function clusters. Cluster 1 includes patients with better lung function attributes compared to the other clusters. Airflow limitation is attenuated in clusters 1 to 4 but more pronounced in clusters 5 to 7. Static hyperinflation is more dominant in clusters 5 to 7. A different pattern occurs for carbon monoxide diffusing capacity, mouth pressures and for arterial blood gases. Related to the different lung function profiles, clusters 1 and 4 demonstrate the best functional performance and health status while this is worst for clusters 6 and 7. All clusters show differences in dyspnea score, proportion of men/women, age, number of exacerbations and hospitalizations, proportion of patients using long-term oxygen and number of comorbidities. Conclusion Based on an integrated assessment of lung function variables, seven pathophysiological clusters can be identified in COPD patients. These clusters poorly predict functional performance and health status. |
| Databáze: | OpenAIRE |
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