Serum C-Reactive Protein and Risk of Pancreatic Cancer in Two Nested, Case–Control Studies
| Autor: | Barry I. Graubard, Michael Pollak, Yuzhen Tao, Stephanie J. Weinstein, Debra T. Silverman, Demetrius Albanes, Rachael Z. Stolzenberg-Solomon, Jarmo Virtamo, Jason B. Douglas |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology Pathology medicine.medical_specialty Epidemiology alpha-Tocopherol Adenocarcinoma Risk Assessment Article Cohort Studies Placebos Double-Blind Method Risk Factors Prostate Internal medicine Pancreatic cancer medicine Humans Prospective cohort study Aged Cancer prevention biology business.industry C-reactive protein Cancer Vitamins Middle Aged Prognosis beta Carotene medicine.disease Pancreatic Neoplasms C-Reactive Protein medicine.anatomical_structure Case-Control Studies Nested case-control study biology.protein Female business Follow-Up Studies |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 20:359-369 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-10-1024 |
| Popis: | Background: Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results. Methods: We conducted two nested, case–control studies in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to test whether prediagnostic circulating CRP concentrations were associated with pancreatic adenocarcinoma. Between 1985 and 2004, 311 cases occurred in ATBC and between 1994 and 2006, 182 cases occurred in PLCO. Controls (n = 510 in ATBC, n = 374 in PLCO) were alive at the time the case was diagnosed and were matched by age, date of blood draw, sex, and race. We used conditional logistic regression adjusted for smoking to calculate OR and 95% CI for pancreatic cancer. Results: CRP concentrations (ng/mL) tended to be inversely or not associated with pancreatic cancer risk in ATBC, PLCO, and combined analyses [per standardized quintile increase in CRP, continuous OR = 0.94 (95% CI, 0.89–0.99), OR = 0.99 (95% CI, 0.95–1.04), OR = 0.98 (95% CI, 0.95–1.01), respectively]. In combined analyses, we observed a significant interaction (Pinteraction = 0.02) such that inverse associations were suggestive in younger (OR = 0.95; 95% CI, 0.90–1.01), but not older, participants. Conclusion: Our results do not support the hypothesis that higher CRP concentrations are associated with incident pancreatic cancer. Impact: Our results highlight the importance of investigating more specific biomarkers for inflammation that may reflect the biological mechanisms underlying pancreatic cancer in prospective cohort studies. Cancer Epidemiol Biomarkers Prev; 20(2); 359–69. ©2010 AACR. |
| Databáze: | OpenAIRE |
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