Characterization of Secondary Bacterial Infections and Antibiotic Use in Mechanically Ventilated Patients With COVID-19 Induced Acute Respiratory Distress Syndrome
| Autor: | Jeannie D. Chan, James A. Town, Erik Risa, Chloe Bryson-Cahn, Nandita S Mani, Nicholas J. Johnson, David J. Roach, Christopher Hebert, Jehan Z Budak |
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| Rok vydání: | 2021 |
| Předmět: |
ARDS
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Acute respiratory distress mechanical ventilation Critical Care and Intensive Care Medicine antibiotic use Internal medicine nosocomial infections Medicine Humans Antibiotic use Clinical syndrome Retrospective Studies Original Research High rate Mechanical ventilation Respiratory Distress Syndrome business.industry SARS-CoV-2 COVID-19 Retrospective cohort study Bacterial Infections medicine.disease Respiration Artificial Anti-Bacterial Agents business |
| Zdroj: | Journal of Intensive Care Medicine |
| ISSN: | 1525-1489 |
| Popis: | Background: COVID-19 has a widely variable clinical syndrome that is difficult to distinguish from bacterial sepsis, leading to high rates of antibiotic use. Early studies indicate low rates of secondary bacterial infections (SBIs) but have included heterogeneous patient populations. Here, we catalogue all SBIs and antibiotic prescription practices in a population of mechanically ventilated patients with COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This was a retrospective cohort study of all patients with COVID-19 ARDS requiring mechanical ventilation from 3 Seattle, Washington hospitals in 2020. Data were obtained via electronic and manual review of the electronic medical record. We report the incidence and site of SBIs, mortality, and antibiotics per day using descriptive statistics. Results: We identified 126 patients with COVID-19 induced ARDS during the study period. Of these patients, 61% developed clinical infection confirmed by bacterial culture. Ventilator associated pneumonia was confirmed in 55% of patients, bacteremia in 20%, and urinary tract infection (UTI) in 17%. Staphylococcus aureus was the most commonly isolated bacterial species. A total of 97% of patients received antibiotics during their hospitalization, and patients received nearly one antibiotic per day during their hospital stay. Conclusions: Mechanically ventilated patients with COVID-19 induced ARDS are at high risk for secondary bacterial infections and have extensive antibiotic exposure. |
| Databáze: | OpenAIRE |
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