Myeloperoxidase as an important predictor of cardiovascular risk in individuals with rheumatoid arthritis
| Autor: | Alceu de Oliveira Toledo Júnior, José Carlos Rebuglio Vellosa, Fábio André dos Santos, Fabiana Postiglioni Mansani, Rômulo Lopes da Costa, Sabrina Grassiolli, Lorena de Freitas Calixto, Bruno Queiroz Zardo, Felício de Freitas Netto, Elisangela Gueiber Montes, Marcelo Derbli Schafranski |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Immunology Physical examination Disease Logistic regression Arthritis Rheumatoid Internal medicine Statistical significance medicine Humans Pharmacology (medical) Glucocorticoids Aged Peroxidase Pharmacology Dose-Response Relationship Drug medicine.diagnostic_test biology business.industry Significant difference Middle Aged medicine.disease C-Reactive Protein Cross-Sectional Studies Cardiovascular Diseases Heart Disease Risk Factors Rheumatoid arthritis Myeloperoxidase biology.protein Female business Glucocorticoid medicine.drug |
| Zdroj: | Inflammopharmacology. 29:1819-1827 |
| ISSN: | 1568-5608 0925-4692 |
| Popis: | Background: Rheumatoid arthritis is an inflammatory disease with joint manifestations. In the presence of extra-articular manifestations, the morbidity and severity of the disease increases. Glucocorticoid is used as a treatment and may result in side effects related to cardiovascular risk. Methods: This was a cross-sectional study including 59 volunteers with rheumatoid arthritis receiving treatment at a Hospital of Campos Gerais, that aimed to establish the relation between cardiovascular risk, glucocorticoid treatment and myeloperoxidase in these patients. Subjects were divided into two groups: using (n = 39) and without glucocorticoids (n = 20). They underwent clinical evaluation, physical examination and blood samples were taken. Statistical analysis was performed using Student's t-test and Mann-Whitney test. Logistic regression was performed to assess cardiovascular risk. The significance level was 5% (α = 0.05). Calculations were performed using the Statistical Package for the Social Science version 21.0. Results: There has been a significant difference between groups in blood glucose values (p = 0.012), that can be explained by the different percentage of diabetic patients in the groups. When assessed cardiovascular risk using the predictors of glucocorticoid dose, time of glucocorticoid use, myeloperoxidase, and C-reactive protein together, these were responsible for significantly predicting cardiovascular risk (p = 0.015). Conclusions: A significant relation between the predictor myeloperoxidase alone was also demonstrated (p = 0.037), may it be an important predictor of cardiovascular risk among individuals with rheumatoid arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink