Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) Syndrome and Carcinoid Tumors With/Without NECH: A Clinicopathologic, Radiologic, and Immunomolecular Comparison Study
| Autor: | Federica Zito Marino, Ludovic Fournel, Giulio Rossi, Enrico Maria Silini, Maria Cecilia Mengoli, Renato Franco, Luca Ampollini, Vincent Cottin, Thomas V. Colby, Letizia Gnetti, Filippo Lococo, Paolo Spagnolo, Mario Migaldi, Marcello Tiseo, Alberto Cavazza |
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| Přispěvatelé: | Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Mengoli, Maria Cecilia, Rossi, Giulio, Cavazza, Alberto, Franco, Renato, Marino, Federica Zito, Migaldi, Mario, Gnetti, Letizia, Silini, Enrico Maria, Ampollini, Luca, Tiseo, Marcello, Lococo, Filippo, Fournel, Ludovic, Spagnolo, Paolo, Cottin, Vincent, Colby, Thomas V., ZITO MARINO, Federica |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Lung Diseases
Male Pathology Lung Neoplasms [SDV]Life Sciences [q-bio] Carcinoid Tumor/*chemistry/diagnostic imaging/pathology 0302 clinical medicine Diagnosis Anaplastic lymphoma kinase Lung Neuroendocrine cell Syndrome Hyperplasia Middle Aged Constrictive Bronchiolitis Prognosis Immunohistochemistry X-Ray Computed medicine.anatomical_structure 030220 oncology & carcinogenesis Female Anatomy medicine.symptom Adult medicine.medical_specialty Carcinoid tumors Tomography Tumor/*analysis Lung/*chemistry/diagnostic imaging/pathology Carcinoid Tumor Air trapping Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences Young Adult DIPNECH Syndrome Carcinoid Tumors Neuroendocrine Cells Predictive Value of Tests Biomarkers Tumor medicine Humans Aged business.industry Lung Neoplasms/*chemistry/diagnostic imaging/pathology Lung Diseases/diagnostic imaging/*metabolism/pathology medicine.disease 030228 respiratory system Neuroendocrine Cells/*chemistry/pathology Differential Surgery Differential diagnosis Tomography X-Ray Computed business Biomarkers |
| Zdroj: | American Journal of Surgical Pathology American Journal of Surgical Pathology, Lippincott, Williams & Wilkins, 2018, 42 (5), pp.646-655. ⟨10.1097/PAS.0000000000001033⟩ |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/PAS.0000000000001033⟩ |
| Popis: | The diagnostic criteria of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) are not well defined, and DIPNECH can be mistaken for carcinoids associated with neuroendocrine cell hyperplasia (NECH). In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH. None of the cases displayed molecular alterations or anaplastic lymphoma kinase expression. Compared with individuals with carcinoids with/without NECH, patients with DIPNECH were more likely to be female individuals (P\\textless0.0001), nonsmokers (P=0.021), and symptomatic, and to have an obstructive/mixed respiratory defect, peripheral location of the lesions, and air trapping (P\\textless0.0001) on chest computed tomography, and constrictive bronchiolitis on histology (P\\textless0.0001). Among immunohistochemical markers, DIPNECH was associated with higher expression of thyroid transcription factor-1, CD10, and gastrin-releasing peptide/bombesin-like peptide (P\\textless0.0001). Yet, when a purely histopathologic definition of DIPNECH was applied, 40% of isolated carcinoids also met the diagnostic criteria for DIPNECH, even in the absence of symptoms and/or radiologic abnormalities. Therefore, as DIPNECH represents a distinct clinical syndrome, we suggest the term DIPNECH be limited to cases presenting with respiratory symptoms, functional and/or radiologic abnormalities, and constrictive bronchiolitis on histology. |
| Databáze: | OpenAIRE |
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