Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus
| Autor: | Yvonne H M Krul-Poel, Frank Stam, Sanne Westra, Paul Lips, Frans Pouwer, H. J. J. van Wijland, Suat Simsek, M. M. ter Wee |
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| Přispěvatelé: | Epidemiology and Data Science, Internal medicine, EMGO - Musculoskeletal health, Medical psychology, ICaR - Circulation and metabolism, Medical and Clinical Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
type 2 diabetes mellitus Endocrinology Diabetes and Metabolism vitamin D 030209 endocrinology & metabolism Placebo lcsh:Diseases of the endocrine glands. Clinical endocrinology Placebo group law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Randomized controlled trial Quality of life law Internal medicine Internal Medicine Vitamin D and neurology Medicine 030212 general & internal medicine lcsh:RC648-665 Vitamin d supplementation business.industry Research Type 2 Diabetes Mellitus health-related quality of life chemistry Physical therapy business Cholecalciferol RCT |
| Zdroj: | Endocrine Connections, 5(6), 61-69. BioScientifica Ltd. Endocrine Connections, Vol 5, Iss 6, Pp 61-69 (2016) Westra, S, Krul-Poel, Y H M, van Wijland, H J, ter Wee-Zaal, M, Stam, F, Lips, P, Pouwer, F & Simsek, S 2016, ' Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus ', Endocrine Connections, vol. 5, no. 6, pp. 61-69 . https://doi.org/10.1530/EC-16-0070 Endocrine Connections Westra, S, Krul-Poel, Y H M, van Wijland, H J, Ter Wee, M M, Stam, F, Lips, P, Pouwer, F & Simsek, S 2016, ' Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus ', Endocrine Connections, vol. 5, no. 6, pp. 61-69 . https://doi.org/10.1530/EC-16-0070 |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/ec-16-0070 |
| Popis: | Objective Increased levels of depressive symptoms, fatigue or pain (all dimensions of reduced health-related quality of life (HRQOL)) are common in people with type 2 diabetes mellitus (DM). Earlier studies have reported associations between low vitamin D status and fatigue and depressive symptoms. The aim of the present study was to examine the effects of vitamin D supplementation on dimensions of HRQOL in people with type 2 DM. Design Randomised, double-blind, placebo-controlled trial. Methods The effect of monthly cholecalciferol 50,000 IU vs placebo on HRQOL was assessed in 275 adults with type 2 DM derived from general practices. HRQOL at baseline and after six months using the Short Form 36 Health Survey (SF-36) was collected. Linear regression analyses were used to compare the change in HRQOL over time between the vitamin D and placebo group. Results 187/275 (68%) completed baseline and follow-up SF-36 and were included in the analysis. Median serum 25-hydroxyvitamin D almost doubled in the intervention group compared to that in the placebo group (58.5–106.0 nmol/L vs 60.0–61.5 nmol/L, respectively). A small significant difference (adjusted B: −8.90; 95% CI: −17.16 to −0.65) between both groups was seen concerning the SF-36 domain role limitations due to physical problems in disadvantage of the vitamin D group. Conclusions Six months of vitamin D supplementation did not improve HRQOL in non-vitamin D-deficient people with type 2 DM managed on oral antidiabetic therapy. |
| Databáze: | OpenAIRE |
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