Iron Supplementation in Twin Pregnancy - The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial
| Autor: | Sharon Maslovitz, Avital Skornick-Rapaport, Shiri Shinar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty medicine.medical_treatment Iron Twins Iron supplement Gastroenterology law.invention 03 medical and health sciences Hemoglobins 0302 clinical medicine Randomized controlled trial law Pregnancy Internal medicine medicine Birth Weight Humans Ferrous Compounds Prospective Studies Genetics (clinical) Twin Pregnancy 030219 obstetrics & reproductive medicine 030109 nutrition & dietetics biology Anemia Iron-Deficiency business.industry Pregnancy Complications Hematologic Obstetrics and Gynecology medicine.disease Ferritin Iron-deficiency anemia Pediatrics Perinatology and Child Health Ferritins biology.protein Pregnancy Twin Gestation Premature Birth Female Hemoglobin business |
| Zdroj: | Twin research and human genetics : the official journal of the International Society for Twin Studies. 20(5) |
| ISSN: | 1832-4274 |
| Popis: | Objective: To assess the efficacy of doubling the daily dose of iron supplement in iron-deficient women with twin pregnancies. Study design: Using a prospective randomized controlled trial, iron-deficient women with twin gestations were randomized to receive a single or a double dose of daily iron from 16 weeks of gestation until 6 weeks postpartum. The primary outcome was hemoglobin at 32 weeks. Secondary outcomes included ferritin at 32 weeks, hemoglobin during pregnancy and postpartum, birth weights, preterm birth rate, gastrointestinal side effects, intravenous iron administration, and compliance with treatment. Results: Eighty-five and 87 women were randomized to receive one capsule (group A) or two capsules (group B) of 34 mg of ferrous sulfate, respectively. Mean hemoglobin (9.6 g/dL and 9.7 g/dL) and ferritin (8.6 ng/ml and 8.5 ng/ml) were similar in both groups A and B, respectively, at allocation. Hemoglobin in group B was significantly higher from 32 weeks onward, until 6 weeks postpartum. There were no significant differences in any of the secondary outcomes examined. Conclusions: In twin pregnancies complicated by iron deficiency anemia, doubling the dose of iron increases hemoglobin and ferritin without worsening gastrointestinal side effects. |
| Databáze: | OpenAIRE |
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