Muscle protein breakdown is impaired during immobilization compared to during a subsequent retraining period in older men: no effect of anti-inflammatory medication
| Autor: | Jakob Agergaard, Anders Ploug Boesen, Søren Reitelseder, Truls Raastad, Kasper Dideriksen, Sigve Nyvik Aas, Lars Holm |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Physiology medicine.drug_class Period (gene) Clinical Biochemistry Ibuprofen Placebo Anti-inflammatory chemistry.chemical_compound Physiology (medical) Internal medicine medicine Humans Receptor Muscle Skeletal Aged Muscle protein Aged 80 and over Nonsteroidal Muscle degradation business.industry Muscle disuse Anti-Inflammatory Agents Non-Steroidal Resistance training Muscle recovery Middle Aged NSAID body regions Endocrinology chemistry Protein Biosynthesis Proteolysis Original Article business human activities Deuterated alanine Deuterated water medicine.drug Physical Conditioning Human |
| Zdroj: | Pflugers Archiv Dideriksen, K, Reitelseder, S, Agergaard, J, Boesen, A P, Aas, S N, Raastad, T & Holm, L 2020, ' Muscle protein breakdown is impaired during immobilization compared to during a subsequent retraining period in older men : no effect of anti-inflammatory medication ', Pflugers Archiv European Journal of Physiology, vol. 472, no. 2, pp. 281-292 . https://doi.org/10.1007/s00424-020-02353-w |
| ISSN: | 1432-2013 |
| DOI: | 10.1007/s00424-020-02353-w |
| Popis: | Muscle inactivity reduces muscle protein synthesis (MPS), whereas a subsequent period of rehabilitation resistance training (retraining) increases MPS. However, less is known regarding muscle protein breakdown (MPB) during such conditions. Furthermore, nonsteroidal anti-inflammatory drugs (NSAIDs) may have a dampening effect on MPB during periods of inactivity in older individuals. Thus, we measured the average MPB, by use of the deuterated water methodology, during an immobilization period and a subsequent retraining period in older individuals with and without NSAID treatment. Eighteen men (60–80 years: range) were randomly assigned to ibuprofen (1200 mg/d, Ibu) or placebo (Plc). One lower limb was immobilized in a cast for 2 weeks and retrained for 2 weeks, and 2 × 20 g of whey protein was ingested daily during both periods. Besides MPB, the protein expression of different muscle degradation signaling molecules was investigated. MPB was lower during immobilization compared to retraining (p p > 0.05). The protein expression of muscle degradation signaling molecules changed during the study intervention but were unaffected by NSAID treatment. The finding that MPB was lower during immobilization than during retraining indicates that an increased MPB may play an important role in the muscle protein remodeling processes taking place within the initial retraining period. Moreover, NSAID treatment did not significantly influence the MPB rate during 2 weeks of lower limb immobilization or during 2 weeks of subsequent retraining in older individuals. |
| Databáze: | OpenAIRE |
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