Skin Toxicity of propranolol in guinea pigs
| Autor: | Ichiro Kobayashi, Kyoko Hosaka, Chohachi Konno, Munekazu Gemba, Masashi Kamiyama, Yuji Saeki, Hiroki Maruo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Adrenergic beta-Antagonists Guinea Pigs Propranolol Pharmacology Toxicology medicine.disease_cause Guinea pig Animals Medicine Photosensitivity Disorders Antihypertensive Agents Sensitization Skin integumentary system business.industry Skin sensitization Skin toxicity medicine.anatomical_structure Anesthesia Toxicity Irritants Irritation business Phototoxicity Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | The Journal of Toxicological Sciences. 24:103-112 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.24.103 |
| Popis: | The skin toxicities of propranolol were studied in guinea pigs. In the primary and cumulative skin irritation studies, the skin reactions and the histopathological changes were observed in all animals treated with propranolol, and those tended to increase with the increase of propranolol dosage. The skin reactions increased with the application times of propranolol up to 7 days in the cumulative skin irritation study. In the skin sensitization, the phototoxicity and the skin photosensitization studies, no skin reactions were observed in any animals used in the studies. These results indicate that propranolol caused skin irritation, but was negative for skin sensitization, phototoxicity and skin photosensitization in guinea pigs. |
| Databáze: | OpenAIRE |
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