Evaluation of the Adjuvant Efficacy of Natural Herbal Medicine on COVID-19: A Retrospective Matched Case-Control Study
| Autor: | Xinghua Li, Gong Qi Chen, Xin Chun Zheng, Xi Liu, Ming Xing Huang, Hai Tao Zhang, Zhong Si Hong, Jin Yu Xia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty China medicine.medical_treatment Pneumonia Viral Traditional Chinese medicine Cohort Studies 03 medical and health sciences Betacoronavirus 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Medicine Chinese Traditional Pandemics Aged Retrospective Studies business.industry SARS-CoV-2 Case-control study COVID-19 Retrospective cohort study General Medicine Middle Aged Combined Modality Therapy Clinical trial Hospitalization Diarrhea Treatment Outcome Complementary and alternative medicine Case-Control Studies Cohort Female Plant Preparations medicine.symptom business Coronavirus Infections Tomography X-Ray Computed Adjuvant 030217 neurology & neurosurgery Cohort study Drugs Chinese Herbal Phytotherapy |
| Zdroj: | The American Journal of Chinese Medicine |
| ISSN: | 1793-6853 |
| Popis: | Since the outbreak of Corona Virus Disease 2019 (COVID-19) in Hubei province, the epidemic scale has increased rapidly, and no effective antiviral drug therapy has been identified yet. This study aimed to evaluate the adjuvant efficacy of Natural Herbal Medicine (NHM) combined with Western medicine in the treatment of COVID-19. We performed a retrospective, 1:1 matched, case-control study of the first cohort of hospitalized COVID-19-confirmed cases (January 17, 2020 to January 28, 2020). A total of 22 of the 36 confirmed patients were included in this study, split into two groups of 11: the NHM group (NHM combined standard Western medicine treatment) and control group (standard Western medicine treatment alone). All patients received appropriate supportive care and regular clinical and laboratory monitoring. Main evaluation indicators included improvement of clinical symptoms such as fever, cough and diarrhea after hospitalization; pathogen nucleic acid test result of respiratory tract and fecal specimens of the patient after hospitalization, and change of chest CT examination after hospitalization. The duration of fever in the NHM group ([Formula: see text] days) was significantly shorter than that in the control group ([Formula: see text] days) ([Formula: see text]). During the whole hospitalization period, the number of cases with diarrhea in the NHM group (two cases) was less than that in the control group (eight cases) ([Formula: see text]). Compared with the control group ([Formula: see text]), the duration for improvement (DI) of chest CT in the NHM group ([Formula: see text]) was significantly shorter ([Formula: see text]). Our results suggest that NHM could improve the clinical symptoms of COVID-19 patients and may be effective in treating COVID-19; thus, a larger, prospective, randomized, controlled clinical trial should be conducted to further evaluate the adjuvant efficacy of NHM in the treatment of COVID-19. |
| Databáze: | OpenAIRE |
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